CYCLIZATION PROCEDURES TOWARD THE SYNTHESIS OF SOME CONFORMATIONALLY RESTRICTED NITROGEN HETEROCYCLES
نویسندگان
چکیده
منابع مشابه
Synthesis of Heterocycles by Intramolecular Cyclization of Organic Azides
A review of synthetic methodologies reported in the last five years that yield N-heterocyclic products by intramolecular cyclization of organic azides with a particular emphasis on transformations catalyzed by metal complexes is presented. These reactions have been classified according to the ring size of the formed heterocycle.
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Four conformationally restricted analogues of pentamidine were prepared. Then, different concentrations (0.039, 0.078, 0.156, 0.312 and 0.625 mg/mL) of each compound and two positive controls (amphotericin B and pentamidine, 0.625 mg/mL), one negative control (culture medium) and one solvent control (DMSO) were prepared and placed in 24-well plates containing 50000 parasite per well. Promastigo...
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Alkyliminoacetonitrile derivatives were investigated as dienophiles in the Diels-Alder reaction. These activated imines react with dienes in intramolecular [4+2] cycloadditions to provide products with either the quinolizidine or indolizidine ring system, depending on the length of the tether connecting diene and dienophile. Quinolizidine cycloadducts are formed in good yield and with high ster...
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A Cu-promoted cyclization of 2-nitrophenyl iodoacetylenes provides a direct route to a range of 2-iodoisatogens. These compounds represent useful intermediates for the late-stage elaboration of the C-I bond to furnish isatins and a range of alternative heterocyclic products.
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ژورنال
عنوان ژورنال: Boletín de la Sociedad Chilena de Química
سال: 2002
ISSN: 0366-1644
DOI: 10.4067/s0366-16442002000100006